Identification of a Mammalian Melanosomal Matrix Glycoprotein
نویسندگان
چکیده
منابع مشابه
Mammalian melanosomal proteins: characterization by polyacrylamide gel electrophoresis.
For many years the major problem impeding the elucidation of the structure of melanin and the melanosome has been the insolubility of the melanin polymer. To date, alkaline and acid hydrolysis seem to be the only methods available which can completely solubilize the melanosome (1); unfortunately, both methods degrade the constituents of the organelle other than the melanin polymer. The recent e...
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Melanocytes present in skin and other organs synthesize and store melanin pigment within membrane-delimited organelles called melanosomes. Exposure of human skin to ultraviolet radiation (UV) stimulates melanin production in melanosomes, followed by transfer of melanosomes from melanocytes to neighboring keratinocytes. Melanosomal function is critical for protecting skin against UV radiation, b...
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The Rh blood group proteins are well known as the erythrocyte targets of the potent antibody response that causes hemolytic disease of the newborn. These proteins have been described in molecular detail; however, little is known about their function. A transport function is suggested by their predicted structure and from phylogenetic analysis. To obtain evidence for a role in solute transport, ...
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The Quail Neuroretina clone 71 gene (QNR-71) is expressed during the differentiation of retinal pigmented epithelia and the epidermis. It encodes a type I transmembrane glycoprotein that shares significant sequence homologies with several melanosomal proteins. We have studied its intracellular traffic in both pigmented and non-pigmented cells. We report that a di-leucine-based sorting signal (E...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1993
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12363626